Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23465931 | 0.86 | TDP1 (0.39) | TDP1MAPK1ALDH1A1CYP3A4TSHR | |
| SCHEMBL17848464 | 0.80 | GRIN2D (0.44) | TDP1MAPK1ALDH1A1CYP3A4TSHR | |
| SCHEMBL11033785 | 0.80 | ALDH1A1 (0.37) | TDP1MAPK1ALDH1A1CYP3A4TSHR | |
| SCHEMBL11033782 | 0.80 | ALDH1A1 (0.37) | TDP1MAPK1ALDH1A1CYP3A4TSHR | |
| SCHEMBL25513382 | 0.79 | ACHE (0.44) | TDP1ALDH1A1CYP3A4TSHRTEAD4 | |
| SCHEMBL20475926 | 0.77 | MAPT (0.37) | MAPK1ALDH1A1TSHRMAPTMAOA | |
| SCHEMBL20228041 | 0.77 | TDP1 (0.38) | TDP1MAPK1ALDH1A1CYP3A4TSHR | |
| SCHEMBL25283157 | 0.76 | MAPT (0.50) | TDP1MAPK1ALDH1A1CYP3A4TSHR | |
| SCHEMBL16023551 | 0.75 | CYP3A4 (0.43) | TDP1MAPK1ALDH1A1CYP3A4TSHR | |
| SCHEMBL29927719 | 0.75 | CYP3A4 (0.43) | TDP1MAPK1ALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472386-B2 | Bile acid derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472386-B2 | Bile acid derivatives as FXR agonists and methods of use thereof | NR1H4, GPBAR1, SLC10A1 | TDP1 2842/4885MAPK1 2130/4885ALDH1A1 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.