Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845674 | 0.80 | DYRK1A (0.50) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL16216168 | 0.79 | F2 (0.42) | F2AURKBAURKA | |
| SCHEMBL8824706 | 0.78 | AURKA (0.46) | AURKBAURKABTKJAK2CSF1R | |
| SCHEMBL1843509 | 0.77 | CYP1A2 (0.47) | NOS2PIM1PRKACAGSK3BCLK4 | |
| SCHEMBL1844588 | 0.77 | GRM4 (0.51) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1846887 | 0.77 | HDAC3 (0.49) | AURKBAURKADYRK1APIM1CLK1 | |
| SCHEMBL1847393 | 0.76 | SMN1; SMN2 (0.51) | TAAR1ADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL1848506 | 0.74 | ADRA2A (0.50) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1844265 | 0.73 | PIM1 (0.49) | AURKADYRK1APTGESPIM1CLK4 | |
| SCHEMBL8824643 | 0.72 | MAPT (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567029-A1 | COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS | Lantheus Medical Imaging, Inc. (US) | 2019-11-13 | — | — | EP | disclosed |