Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8824712 | 0.78 | ROCK1 (0.54) | MAPTMEN1KMT2AEGFRALDH1A1 | |
| SCHEMBL17911903 | 0.77 | TAAR1 (0.55) | MAPTMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8824655 | 0.76 | MAPT (0.52) | MAPTMEN1KMT2AEGFRALDH1A1 | |
| SCHEMBL1844588 | 0.76 | GRM4 (0.51) | KMT2AEGFRIGF1RKCNN3 | |
| SCHEMBL1845674 | 0.76 | DYRK1A (0.50) | ALDH1A1KDM4E | |
| SCHEMBL1843509 | 0.76 | CYP1A2 (0.47) | MAPTMEN1KMT2AALDH1A1KCNN3 | |
| SCHEMBL2025299 | 0.76 | RAB9A (0.63) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL20549245 | 0.76 | FABP1 (0.58) | MAPTMEN1KMT2AEGFRALDH1A1 | |
| SCHEMBL1848506 | 0.76 | ADRA2A (0.50) | MAPTEGFRALDH1A1IGF1RTSHR | |
| SCHEMBL1847393 | 0.75 | SMN1; SMN2 (0.51) | MEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681833-A | ADMINSTERING FOR TREATMENT OF PEPTIC ULCER | MERCK, SHARP & DOHME LTD. (GB) | 1997-10-28 | — | — | US | disclosed |
| EP-0636123-A1 | 3-UREIDO SUBSTITUTED BENZODIAZEPIN-2-ONES HAVING CHOLECYSTOKININ AND/OR GASTRIN ANTAGONISTIC ACTIVITY AND THEIR USE IN THERAPY | MERCK SHARP & DOHME LTD. (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993019052-A1 | 3-UREIDO SUBSTITUTED BENZODIAZEPIN-2-ONES HAVING CHOLECYSTOKININ AND/OR GASTRIN ANTAGONISTIC ACTIVITY AND THEIR USE IN THERAPY | MERCK SHARP & DOHME LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |