Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20503980 | 0.83 | OPRM1 (0.40) | OPRM1OPRL1CDK8AXLSLC6A2 | |
| SCHEMBL20504109 | 0.76 | OPRM1 (0.40) | OPRM1OPRL1CDK8AXLSLC6A2 | |
| SCHEMBL856151 | 0.73 | PIK3CA (0.51) | CDK8AXLSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18860575 | 0.71 | KDM4E (0.48) | OPRM1OPRL1CDK8AXLSLC6A2 | |
| SCHEMBL20503942 | 0.70 | SLC6A2 (0.41) | OPRM1OPRL1CDK8AXLSLC6A2 | |
| SCHEMBL20503943 | 0.70 | SLC6A2 (0.41) | OPRM1OPRL1CDK8AXLSLC6A2 | |
| SCHEMBL18860531 | 0.70 | KDM4E (0.47) | OPRM1OPRL1CDK8AXLSLC6A2 | |
| SCHEMBL20504089 | 0.69 | PIK3CA (0.48) | CDK8AXLSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20504127 | 0.69 | SLC6A2 (0.42) | OPRM1OPRL1CDK8AXLSLC6A2 | |
| SCHEMBL18860564 | 0.68 | MET (0.44) | OPRM1OPRL1CDK8AXLSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377491-B1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2019-11-13 | — | — | EP | disclosed |