Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21939632 | 0.82 | SLC22A1 (0.50) | ALDH1A1MEN1KMT2ATDP1LMNA | |
| SCHEMBL320332 | 0.79 | ALDH1A1 (0.64) | GABRA1GABRB2ALDH1A1MEN1KMT2A | |
| SCHEMBL26028903 | 0.79 | ALDH1A1 (0.46) | GABRA1GABRB2ALDH1A1MEN1KMT2A | |
| SCHEMBL954101 | 0.78 | ALDH1A1 (0.40) | GABRA1GABRB2ALDH1A1MEN1KMT2A | |
| SCHEMBL19880549 | 0.77 | KMT2A (0.45) | GABRA1GABRB2ALDH1A1MEN1KMT2A | |
| SCHEMBL24398979 | 0.75 | GABRA1 (0.36) | GABRA1GABRB2LMNACYP1A2TSHR | |
| SCHEMBL13480295 | 0.75 | NPSR1 (0.53) | ALDH1A1MEN1KMT2ATDP1LMNA | |
| SCHEMBL21205734 | 0.74 | GABRA1 (0.42) | GABRA1GABRB2ALDH1A1MEN1KMT2A | |
| SCHEMBL21538100 | 0.74 | POLB (0.47) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL11745960 | 0.71 | GABRA1 (0.46) | GABRA1GABRB2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019215470-A1 | USE OF GUANABENZ OR DERIVATES THEREOF FOR THE TREATMENT OF TYPE I IFN-DEPENDENT PATHOLOGIES | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-11-14 | — | — | WO | disclosed |