⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20411271 | 1.00 | — | — | |
| SCHEMBL21562205 | 0.78 | — | — | |
| SCHEMBL7975032 | 0.70 | — | — | |
| SCHEMBL19543049 | 0.67 | LMNA (0.33) | — | |
| SCHEMBL20411276 | 0.65 | — | — | |
| SCHEMBL28590301 | 0.64 | LMNA (0.30) | — | |
| SCHEMBL24969592 | 0.64 | — | — | |
| SCHEMBL18016573 | 0.63 | — | — | |
| SCHEMBL26035481 | 0.62 | — | — | |
| SCHEMBL19543432 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187617-A9 | DOSING OF SIRNA COMPOUNDS TO THE CISTERNA MAGNA | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2019217459-A1 | EXTRAHEPATIC DELIVERY | ALNYLAM PHARMACEUTICALS, INC. (US) | 2019-11-14 | — | — | WO | disclosed |