Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5078261 | 0.89 | HDAC6 (1.00) | HDAC8HDAC6HDAC2HDAC1 | |
| SCHEMBL5078264 | 0.89 | HDAC6 (1.00) | HDAC8HDAC6HDAC2HDAC1 | |
| SCHEMBL5078936 | 0.84 | HDAC2 (0.80) | HDAC8HDAC6HDAC2 | |
| SCHEMBL5078305 | 0.84 | HDAC8 (0.81) | HDAC8HDAC6HDAC2HDAC1 | |
| SCHEMBL6007674 | 0.81 | HDAC8 (0.62) | HDAC8HDAC6HDAC2HDAC1 | |
| SCHEMBL7057266 | 0.81 | HDAC8 (0.62) | HDAC8HDAC6HDAC2HDAC1 | |
| SCHEMBL7826899 | 0.81 | HDAC6 (0.62) | HDAC8HDAC6HDAC2HDAC1 | |
| SCHEMBL2079073 | 0.80 | HDAC8 (0.61) | HDAC8HDAC6HDAC2HDAC1 | |
| SCHEMBL21563554 | 0.80 | HDAC8 (0.61) | HDAC8HDAC6HDAC2HDAC1 | |
| SCHEMBL8066345 | 0.80 | HDAC8 (0.61) | HDAC8HDAC6HDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940805-A1 | BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2008-07-09 | — | — | EP | disclosed |
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | METHYLGENE, INC. (CA) | 2007-07-05 | — | — | US | disclosed |
| WO-2007022638-A1 | BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | HDAC5, HDAC4, HDAC3 | HDAC8 9/4885HDAC6 24/4885HDAC2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.