Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ESRRB | O95718 | 3/20 | 0.31 |
| ▸ | ESRRG | P62508 | 3/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21564667 | 0.91 | ALDH1A1 (0.33) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL21564561 | 0.89 | TLR8 (0.40) | ALDH1A1USP2MEN1KMT2AMAPT | |
| SCHEMBL21564682 | 0.88 | NOTUM (0.34) | KDM1ANOTUMTP53 | |
| SCHEMBL21564847 | 0.78 | SLC6A2 (0.32) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL21564491 | 0.78 | MEN1 (0.42) | ALDH1A1LMNAMEN1KMT2ATP53 | |
| SCHEMBL21564585 | 0.78 | — | — | |
| SCHEMBL21564542 | 0.78 | KDM1A (0.36) | KDM1ATP53 | |
| SCHEMBL21564896 | 0.77 | KMT2A (0.36) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL21553144 | 0.76 | NPC1 (0.39) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL21552986 | 0.75 | MAPK1 (0.40) | KDM1AALDH1A1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019217972-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES, INC. (US) | 2019-11-14 | — | — | WO | disclosed |