Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29891163 | 1.00 | RET (0.45) | RETSYKOPRK1CKS1BSKP1 | |
| SCHEMBL28542250 | 1.00 | RET (0.45) | RETSYKOPRK1CKS1BSKP1 | |
| SCHEMBL28542249 | 1.00 | RET (0.45) | RETSYKOPRK1CKS1BSKP1 | |
| SCHEMBL21564574 | 1.00 | RET (0.45) | RETSYKOPRK1CKS1BSKP1 | |
| SCHEMBL28709581 | 0.89 | RET (0.55) | RETSYKOPRK1CKS1BSKP1 | |
| SCHEMBL389068 | 0.85 | SYK (0.53) | RETSYKCKS1BSKP1SKP2 | |
| SCHEMBL390147 | 0.85 | SYK (0.53) | RETSYKCKS1BSKP1SKP2 | |
| SCHEMBL389069 | 0.85 | SYK (0.53) | RETSYKCKS1BSKP1SKP2 | |
| SCHEMBL21551489 | 0.85 | OPRK1 (0.45) | SYKOPRK1JAK3CHRM4 | |
| SCHEMBL21551488 | 0.85 | OPRK1 (0.45) | SYKOPRK1JAK3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019215341-A1 | FURIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-11-14 | — | — | WO | disclosed |