Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21564837 | 0.89 | HRH4 (0.40) | NPC1RAB9ATP53ALDH1A1MEN1 | |
| SCHEMBL23258213 | 0.89 | HRH4 (0.39) | TP53ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL21553144 | 0.88 | NPC1 (0.39) | NPC1RAB9ANPSR1TP53MAPT | |
| SCHEMBL21553049 | 0.84 | AR (0.37) | NPC1RAB9ANPSR1TP53MAPT | |
| SCHEMBL21552901 | 0.83 | NPC1 (0.41) | NPC1RAB9ANPSR1TP53MAPT | |
| SCHEMBL21564515 | 0.81 | GRIA1 (0.42) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL21564780 | 0.78 | GABRA2 (0.43) | NPC1RAB9ANPSR1MAPTALDH1A1 | |
| SCHEMBL21553098 | 0.78 | GFER (0.38) | TP53MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL21564469 | 0.77 | ALDH1A1 (0.43) | TP53MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL21564491 | 0.77 | MEN1 (0.42) | NPC1RAB9ATP53ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019217972-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES, INC. (US) | 2019-11-14 | — | — | WO | disclosed |