Sugi Predict

Sugi Predict / Compounds / SCHEMBL21564641

SCHEMBL21564641

SCHEMBL21564641

CCOC(=O)CCc1c[nH]c(=O)c(N2CCN(C(=O)OC(C)(C)C)CC2)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 2/20 0.44
▸ KDM4E B2RXH2 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ GLA P06280 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ RECQL P46063 1/20 0.44
▸ MAPT P10636 2/20 0.40
▸ GBA1 P04062 2/20 0.39
▸ CKS1B P61024 2/20 0.39
▸ SKP1 P63208 2/20 0.39
▸ SKP2 Q13309 2/20 0.39
▸ ATM Q13315 1/20 0.38
▸ KIT P10721 1/20 0.38
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ TLR9 Q9NR96 1/20 0.36
▸ ACKR3 P25106 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21553106 0.86 MAPT (0.39) HSD17B10KDM4EALDH1A1HPGDMAPT
SCHEMBL21552879 0.84 ALDH1A1 (0.39) HSD17B10KDM4EALDH1A1MAPTMEN1
SCHEMBL21564523 0.83 GBA1 (0.41) KDM4EALDH1A1MAPTGBA1CKS1B
SCHEMBL23258216 0.81 GBA1 (0.45) KDM4EALDH1A1MAPTGBA1CKS1B
SCHEMBL21564861 0.79 GRIA1 (0.41) HSD17B10KDM4EALDH1A1GLAHPGD
SCHEMBL21564480 0.78 MAPT (0.39) HSD17B10KDM4EMAPTGBA1CKS1B
SCHEMBL21564652 0.77 GBA1 (0.47) KDM4EALDH1A1MAPTGBA1CKS1B
SCHEMBL21564640 0.75 CKS1B (0.40) HSD17B10KDM4EALDH1A1GLAHPGD
SCHEMBL21564476 0.75 KMT2A (0.41) HSD17B10KDM4EALDH1A1GLAHPGD
SCHEMBL21564820 0.75 GPR119 (0.38) HSD17B10KDM4EALDH1A1GLAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112513020-B KDM1A inhibitors for the treatment of diseases 伊美格生物科学公司 2024-02-23 — — CN disclosed
US-20230250090-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES INC (US) 2023-08-10 — — US disclosed
US-20230250090-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES INC (US) 2023-08-10 — — US disclosed
US-11578059-B2 KDM1A inhibitors for the treatment of disease Imago Biosciences. Inc. (US) 2023-02-14 — — US disclosed
US-20210115023-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. 2021-04-22 — — US disclosed
WO-2019217972-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. (US) 2019-11-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230250090-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1B, KDM1A, KDM2A HSD17B10 1762/4885KDM4E 18/4885ALDH1A1 839/4885
US-20210115023-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1A, KDM1B, KDM2A HSD17B10 1947/4885KDM4E 18/4885ALDH1A1 599/4885
US-11578059-B2 KDM1A inhibitors for the treatment of disease KDM1B, KDM1A, KDM2A HSD17B10 1762/4885KDM4E 18/4885ALDH1A1 839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.