Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | WRN | Q14191 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21568188 | 0.92 | DYRK1A (0.61) | DYRK1AHSD17B10HDAC6HDAC3HDAC4 | |
| SCHEMBL21568734 | 0.90 | DYRK1A (0.59) | DYRK1AHSD17B10HDAC6HDAC3HDAC4 | |
| SCHEMBL21568094 | 0.89 | CSNK1D (0.58) | DYRK1AHSD17B10HDAC6HDAC3HDAC4 | |
| SCHEMBL21568093 | 0.88 | DYRK1A (0.59) | DYRK1AHSD17B10HDAC6HDAC3HDAC4 | |
| SCHEMBL21568360 | 0.86 | DYRK1A (0.57) | DYRK1AHSD17B10HDAC6HDAC3HDAC4 | |
| SCHEMBL21568184 | 0.86 | CSNK1D (0.62) | DYRK1AHSD17B10CSNK1DBLMWRN | |
| SCHEMBL21568172 | 0.83 | DYRK1A (0.60) | DYRK1AHSD17B10HDAC6HDAC3HDAC4 | |
| SCHEMBL18154477 | 0.83 | DYRK1A (0.81) | DYRK1AHSD17B10HDAC6HDAC3HDAC4 | |
| SCHEMBL21568967 | 0.82 | BLM (0.54) | DYRK1AHSD17B10BLMWRNMEN1 | |
| SCHEMBL21568287 | 0.82 | DYRK1A (0.61) | DYRK1AHSD17B10HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731985-B2 | Compositions and methods for treating cancer | HB THERAPEUTICS INC. (US) | 2023-08-22 | — | — | US | disclosed |
| WO-2019217509-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | HB THERAPEUTICS INC. (US) | 2019-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731985-B2 | Compositions and methods for treating cancer | VHL, TP53, NUDT1 | DYRK1A 4664/4885HSD17B10 4412/4885HDAC6 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.