Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.39 |
| ▸ | SLC28A3 | Q9HAS3 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacinamide SCHEMBL20398298 | 0.91 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL28136690 | 0.87 | F7 (0.51) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL17315028 | 0.86 | F7 (0.50) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL28137384 | 0.86 | F7 (0.50) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL502654 | 0.85 | F7 (0.49) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL30498617 | 0.84 | F7 (0.48) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL28184048 | 0.84 | F7 (0.48) | F7F3SARM1SIRT2SIRT6 | |
| Ribose (Furanose) SCHEMBL14321532 | 0.84 | F7 (0.59) | F7F3SARM1SIRT2SIRT6 | |
| Ribose (Furanose) SCHEMBL338518 | 0.84 | F7 (0.59) | F7F3SARM1SIRT2SIRT6 | |
| Ribose (Furanose) SCHEMBL18185139 | 0.84 | F7 (0.59) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3794007-A1 | (THIO)NICOTINAMIDE RIBOFURANOSIDE SALTS AND COMPOSITIONS, METHODS OF MAKING, AND USES THEREOF | Roche Diagnostics GmbH (DE) | 2021-03-24 | — | — | EP | disclosed |
| CN-112135833-A | (thio) nicotinamide ribofuranoside salt, composition, preparation method and application thereof | 弗·哈夫曼-拉罗切有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-112135833-A | (thio) nicotinamide ribofuranoside salt, composition, preparation method and application thereof | 弗·哈夫曼-拉罗切有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-112135833-A | (thio) nicotinamide ribofuranoside salt, composition, preparation method and application thereof | 弗·哈夫曼-拉罗切有限公司 | 2020-12-25 | — | — | CN | disclosed |
| WO-2019219895-A1 | (THIO)NICOTINAMIDE RIBOFURANOSIDE SALTS AND COMPOSITIONS, METHODS OF MAKING, AND USES THEREOF | ROCHE DIAGNOSTICS GMBH (DE) | 2019-11-21 | — | — | WO | disclosed |