Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11230500 | 0.81 | LMNA (0.56) | LMNAMAPTATML3MBTL1GAA | |
| SCHEMBL11232238 | 0.81 | LMNA (0.56) | LMNAMAPTATML3MBTL1GAA | |
| SCHEMBL11228075 | 0.81 | LMNA (0.56) | LMNAMAPTATML3MBTL1GAA | |
| SCHEMBL11234134 | 0.81 | LMNA (0.56) | LMNAMAPTATML3MBTL1GAA | |
| SCHEMBL11237197 | 0.79 | LMNA (0.55) | LMNAMAPTATML3MBTL1GAA | |
| SCHEMBL16417679 | 0.79 | LMNA (0.51) | LMNAMAPTATML3MBTL1GAA | |
| SCHEMBL16417708 | 0.79 | LMNA (0.51) | LMNAMAPTATML3MBTL1GAA | |
| SCHEMBL21572852 | 0.78 | ALDH1A1 (0.56) | LMNAMAPTGAAALDH1A1TSHR | |
| SCHEMBL11237216 | 0.78 | LMNA (0.54) | LMNAMAPTATML3MBTL1GAA | |
| SCHEMBL11005721 | 0.77 | TSHR (0.63) | LMNAMAPTALDH1A1TSHRESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3569594-A1 | METHOD FOR THE PREPARATION OF SUBSTITUTED PYRAZINES | Universität Graz (AT) | 2019-11-20 | — | — | EP | disclosed |