Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.36 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2173369 | 0.79 | NR1H4 (0.53) | THRBMAPTNR1H4PIK3CDPIK3R2 | |
| SCHEMBL21574265 | 0.78 | THRB (0.43) | THRBMAPTNR1H4PGRNR3C2 | |
| SCHEMBL22299813 | 0.76 | MAPT (0.54) | MAPTNR1H4KDM4EALDH1A1GAA | |
| SCHEMBL2171061 | 0.74 | MAPT (0.46) | THRBMAPTNR1H4PGRNR3C2 | |
| SCHEMBL2549040 | 0.74 | TP53 (0.55) | MAPTNR1H4KDM4EALDH1A1POLB | |
| SCHEMBL19910470 | 0.71 | NR1H4 (0.43) | THRBMAPTNR1H4PGRNR3C2 | |
| SCHEMBL2171176 | 0.69 | MAPT (0.46) | MAPTNR1H4PGRNR3C2PIK3CD | |
| SCHEMBL2546279 | 0.69 | MAPT (0.55) | THRBMAPTNR1H4KDM4EALDH1A1 | |
| SCHEMBL19910458 | 0.68 | NR1H4 (0.66) | NR1H4 | |
| SCHEMBL21574193 | 0.68 | MAPT (0.44) | THRBMAPTNR1H4PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288948-B1 | FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2019-11-20 | — | — | EP | disclosed |