Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19910420 | 0.80 | NR1H4 (0.44) | NR1H4THRBMAPTPGRAR | |
| SCHEMBL19910368 | 0.78 | NR1H4 (0.45) | NR1H4THRBMAPT | |
| SCHEMBL21574213 | 0.77 | NR1H4 (0.47) | NR1H4MAPT | |
| SCHEMBL19910381 | 0.76 | NR1H4 (0.57) | NR1H4THRBMAPT | |
| SCHEMBL16702292 | 0.71 | NR1H4 (0.69) | NR1H4MAPT | |
| SCHEMBL21574194 | 0.71 | THRB (0.43) | NR1H4THRBMAPTPGRNR3C2 | |
| SCHEMBL21574265 | 0.71 | THRB (0.43) | NR1H4THRBMAPTPGRNR3C2 | |
| SCHEMBL2173369 | 0.70 | NR1H4 (0.53) | NR1H4THRBMAPT | |
| SCHEMBL2549040 | 0.69 | TP53 (0.55) | NR1H4MAPT | |
| SCHEMBL21574193 | 0.69 | MAPT (0.44) | NR1H4THRBMAPTPGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3065738-B1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |