Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19910420 | 0.94 | NR1H4 (0.44) | NR1H4MAPTRXFP1OPRL1TP53 | |
| SCHEMBL19910381 | 0.87 | NR1H4 (0.57) | NR1H4MAPTRXFP1MAOB | |
| SCHEMBL19910470 | 0.77 | NR1H4 (0.43) | NR1H4MAPT | |
| SCHEMBL18198055 | 0.75 | NR1H4 (0.67) | NR1H4MAPT | |
| SCHEMBL16702461 | 0.73 | NR1H4 (0.85) | NR1H4MAPTTP53 | |
| SCHEMBL21574277 | 0.72 | NR1H4 (0.51) | NR1H4MAPTRXFP1MAOB | |
| SCHEMBL19910427 | 0.72 | NR1H4 (0.47) | NR1H4MAPTRXFP1TP53 | |
| SCHEMBL2546275 | 0.71 | NR1H4 (0.65) | NR1H4MAPTRXFP1TP53 | |
| SCHEMBL18191644 | 0.71 | NR1H4 (0.60) | NR1H4MAPTTP53 | |
| SCHEMBL19910368 | 0.71 | NR1H4 (0.45) | NR1H4MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288948-B1 | FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2019-11-20 | — | — | EP | disclosed |