Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 13/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2546275 | 0.74 | NR1H4 (0.65) | NR1H4NOTUMMAPTPOLBRXFP1 | |
| SCHEMBL21574213 | 0.72 | NR1H4 (0.47) | NR1H4MAPTRXFP1TP53 | |
| SCHEMBL19910381 | 0.71 | NR1H4 (0.57) | NR1H4MAPTPOLBRXFP1 | |
| SCHEMBL19910420 | 0.69 | NR1H4 (0.44) | NR1H4MAPTRXFP1TP53 | |
| SCHEMBL19910485 | 0.68 | NR1H4 (0.59) | NR1H4TP53 | |
| SCHEMBL16709823 | 0.68 | NR1H4 (0.55) | NR1H4NOTUMMAPTPOLBTP53 | |
| SCHEMBL22299180 | 0.67 | NR1H4 (0.57) | NR1H4MAPTPOLBTP53 | |
| SCHEMBL2542694 | 0.67 | TP53 (0.58) | NR1H4MAPTPOLBTP53 | |
| SCHEMBL21574214 | 0.67 | NR1H4 (0.55) | NR1H4MAPTPOLB | |
| SCHEMBL18198055 | 0.67 | NR1H4 (0.67) | NR1H4MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3065738-B1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |