Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214570 | 0.84 | GAA (0.55) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL4105577 | 0.84 | GAA (0.55) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL2735268 | 0.77 | GAA (0.65) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL213391 | 0.77 | ALDH1A1 (0.76) | GAAALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL17143115 | 0.75 | SMN1; SMN2 (0.54) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL213525 | 0.74 | GAA (0.58) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL28438962 | 0.72 | HPGD (0.57) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL216639 | 0.72 | MAPT (0.46) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL17142801 | 0.72 | GRM4 (0.55) | GAAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL4570473 | 0.71 | KMT2A (0.57) | GAAALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | claimed |