Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | GRM5 | P41594 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735323 | 0.84 | ALDH1A1 (0.76) | ALDH1A1GAAL3MBTL1KMT2AMEN1 | |
| SCHEMBL30500131 | 0.80 | NPC1 (0.60) | ALDH1A1GAAL3MBTL1KMT2AMEN1 | |
| SCHEMBL215766 | 0.77 | GAA (0.76) | ALDH1A1GAAL3MBTL1KMT2AMEN1 | |
| SCHEMBL17142801 | 0.73 | GRM4 (0.55) | ALDH1A1GAAL3MBTL1KMT2AMEN1 | |
| SCHEMBL17143115 | 0.72 | SMN1; SMN2 (0.54) | ALDH1A1GAAL3MBTL1KMT2AMEN1 | |
| SCHEMBL3859299 | 0.72 | GRM5 (1.00) | L3MBTL1KMT2AMEN1GRM5NPC1 | |
| SCHEMBL438214 | 0.71 | RAB9A (0.70) | GAAL3MBTL1KMT2AMEN1GRM5 | |
| SCHEMBL343999 | 0.71 | GDA (0.63) | ALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL7408674 | 0.71 | RAB9A (0.78) | KMT2AMEN1GRM5NPC1RAB9A | |
| SCHEMBL8473023 | 0.71 | MEN1 (0.65) | GAAL3MBTL1KMT2AMEN1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |