SCHEMBL21577529

SCHEMBL21577529

Fc1cc(C#Cc2ccc(C3CCC(CCC4CC4)CC3)cc2)cc(F)c1N=C=S

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 8/20 0.38
ESR1 P03372 6/20 0.33
CYP2C9 P11712 3/20 0.33
CYP3A4 P08684 2/20 0.33
P2RY14 Q15391 1/20 0.33
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
MEN1 O00255 1/20 0.32
MAPK1 P28482 1/20 0.32
KMT2A Q03164 1/20 0.32
CYP2D6 P10635 1/20 0.31
OPRL1 P41146 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21577522 0.93 ALDH1A1 (0.42) ESR2ESR1CYP2C9CYP3A4P2RY14
SCHEMBL21577534 0.93 ESR2 (0.33) ESR2ESR1CYP2C9CYP3A4P2RY14
SCHEMBL21577523 0.91 MEN1 (0.36) ESR2CYP2C9P2RY14ALDH1A1LMNA
SCHEMBL21577521 0.90 ESR2 (0.32) ESR2ESR1CYP2C9CYP3A4P2RY14
SCHEMBL21577525 0.90 MEN1 (0.35) ESR2CYP2C9P2RY14ALDH1A1LMNA
SCHEMBL21577530 0.88 P2RY14 (0.33) P2RY14
SCHEMBL22666480 0.88 ESR2 (0.34) ESR2ESR1CYP2C9CYP3A4P2RY14
SCHEMBL24390790 0.87 MEN1 (0.41) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL21577535 0.86 HDAC2 (0.33) P2RY14
SCHEMBL21577526 0.86 ESR2 (0.42) ESR2P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11306251-B2 Liquid-crystalline medium MERCK PATENT GMBH (DE) 2022-04-19 US disclosed
WO-2022008474-A1 OPTICAL COMPONENT MERCK PATENT GMBH (DE) 2022-01-13 WO disclosed
US-20190352564-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-11-21 US disclosed