Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363017 | 0.88 | ESR2 (0.48) | ESR2NR1H2MAPK1NAMPTMAPT | |
| SCHEMBL3616837 | 0.87 | ESR2 (0.47) | ESR2NR1H2MAPK1NAMPTMAPT | |
| SCHEMBL21577589 | 0.84 | ESR2 (0.45) | ESR2NR1H2MAPK1NAMPTMAPT | |
| SCHEMBL3059811 | 0.82 | MAPK1 (0.51) | ESR2NR1H2MAPK1NAMPTMAPT | |
| SCHEMBL12021884 | 0.81 | ESR2 (0.46) | ESR2NR1H2MAPK1MAPTLMNA | |
| SCHEMBL21577582 | 0.80 | ESR2 (0.43) | ESR2NR1H2MAPK1NAMPTMAPT | |
| SCHEMBL20356399 | 0.75 | MAPK1 (0.39) | ESR2NR1H2MAPK1NAMPTLMNA | |
| SCHEMBL8363589 | 0.75 | MAPK1 (0.49) | ESR2NR1H2MAPK1NAMPTMAPT | |
| SCHEMBL2261638 | 0.74 | ESR2 (0.45) | ESR2NR1H2MAPK1NAMPTLMNA | |
| SCHEMBL1365173 | 0.73 | NR1H2 (0.72) | ESR2NR1H2MAPK1NAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300948-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2021-09-30 | — | — | US | disclosed |
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200121681-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. | 2020-04-23 | — | — | US | disclosed |
| US-20200113913-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. | 2020-04-16 | — | — | US | disclosed |
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2019-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200113913-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | SHH, WNT3A, WNT1 | ESR2 1631/4885NR1H2 522/4885MAPK1 1383/4885 |
| US-20210300948-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | ESR2 1973/4885NR1H2 1821/4885MAPK1 3170/4885 |
| US-20200121681-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | SHH, GLI1, WNT1 | ESR2 1582/4885NR1H2 248/4885MAPK1 837/4885 |
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | MKI67, PROX1, DCX | ESR2 2125/4885NR1H2 3221/4885MAPK1 2543/4885 |
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | ESR2 1973/4885NR1H2 1821/4885MAPK1 3170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.