Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23874331 | 0.88 | ALDH1A1 (0.54) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL24242893 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ACA2CHKA | |
| SCHEMBL12243151 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ACA2CHKA | |
| SCHEMBL13779985 | 0.81 | ALDH1A1 (0.48) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL2606069 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ACA2CHKA | |
| SCHEMBL23815948 | 0.80 | ALDH1A1 (0.50) | ALDH1A1LMNAMEN1KMT2ATP53 | |
| SCHEMBL3437018 | 0.79 | ALDH1A1 (0.75) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL6997610 | 0.77 | ALDH1A1 (0.70) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL18855590 | 0.75 | ALDH1A1 (0.50) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL27889775 | 0.75 | ALDH1A1 (0.48) | ALDH1A1LMNAMEN1KMT2ALIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2019-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | MKI67, PROX1, DCX | ALDH1A1 30/4885LMNA 3598/4885HTT 2211/4885 |
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | ALDH1A1 65/4885LMNA 3446/4885HTT 3555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.