Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21580095 | 0.91 | NAMPT (0.49) | NAMPTCYP2D6CYP2C9LMNAHTT | |
| SCHEMBL21580050 | 0.83 | HPGD (0.42) | ROCK2ROCK1MAPK14 | |
| SCHEMBL21580049 | 0.82 | NAMPT (0.49) | NAMPTMMP13ROCK2ROCK1CYP3A4 | |
| SCHEMBL21580145 | 0.75 | PPARG (0.41) | ROCK2ROCK1MAPK14 | |
| SCHEMBL21580112 | 0.75 | NAMPT (0.52) | NAMPTCYP2C9HTTSMN1; SMN2HDAC1 | |
| SCHEMBL23686674 | 0.73 | PPARA (0.42) | LMNASMN1; SMN2HDAC1 | |
| SCHEMBL21580052 | 0.71 | NAMPT (0.44) | NAMPTROCK2LMNAHDAC1 | |
| SCHEMBL23692096 | 0.71 | NPC1 (0.43) | MMP13ROCK2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL21580069 | 0.71 | MAPT (0.43) | MMP13ROCK2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL15377165 | 0.70 | NAMPT (0.72) | NAMPTMMP13MAPK14CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11384085-B2 | Modulators of ion channel receptors and uses thereof | BIONOMICS LIMITED (AU) | 2022-07-12 | — | — | US | disclosed |
| US-20210230165-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2021-07-29 | — | — | US | disclosed |
| WO-2019218025-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2019-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230165-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | TRPV1, TRPM8, TRPV2 | NAMPT 2153/4885MMP13 4253/4885ROCK2 3598/4885 |
| US-11384085-B2 | Modulators of ion channel receptors and uses thereof | TRPV1, TRPM8, TRPV2 | NAMPT 2153/4885MMP13 4253/4885ROCK2 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.