Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21580141 | 0.91 | SCN3A (0.48) | NPC1RAB9ASMN1; SMN2LMNAHPGD | |
| SCHEMBL21580075 | 0.89 | HPGD (0.42) | NPC1ROCK2ROCK1LMNAHPGD | |
| SCHEMBL21580041 | 0.88 | NAMPT (0.45) | NPC1RAB9ACYP2D6CYP2C9CYP1A2 | |
| SCHEMBL21580092 | 0.86 | NAMPT (0.47) | NPC1RAB9ACYP2D6CYP2C9CYP1A2 | |
| SCHEMBL21580049 | 0.84 | NAMPT (0.49) | NPC1RAB9ACYP2D6CYP2C9CYP1A2 | |
| SCHEMBL23692096 | 0.84 | NPC1 (0.43) | NPC1RAB9ACYP2D6CYP2C9CYP1A2 | |
| SCHEMBL21580040 | 0.83 | MLLT1 (0.45) | NPC1RAB9ACYP2D6CYP2C9CYP1A2 | |
| SCHEMBL21580037 | 0.82 | EGLN2 (0.43) | NPC1RAB9ACYP2D6CYP2C9CYP1A2 | |
| SCHEMBL21580073 | 0.82 | PLAU (0.45) | NPC1RAB9ACYP2D6CYP2C9CYP1A2 | |
| SCHEMBL21580033 | 0.82 | KDM4E (0.41) | NPC1RAB9AROCK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11384085-B2 | Modulators of ion channel receptors and uses thereof | BIONOMICS LIMITED (AU) | 2022-07-12 | — | — | US | disclosed |
| US-20210230165-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2021-07-29 | — | — | US | disclosed |
| WO-2019218025-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2019-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230165-A1 | MODULATORS OF ION CHANNEL RECEPTORS AND USES THEREOF | TRPV1, TRPM8, TRPV2 | NPC1 1634/4885RAB9A 1974/4885CYP2D6 3005/4885 |
| US-11384085-B2 | Modulators of ion channel receptors and uses thereof | TRPV1, TRPM8, TRPV2 | NPC1 1634/4885RAB9A 1974/4885CYP2D6 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.