Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9572481 | 0.82 | DYRK1A (0.43) | DYRK1ASIRT3TDP1CA12CA2 | |
| SCHEMBL5548862 | 0.81 | DYRK1A (0.40) | DYRK1ASIRT3TDP1CA12CA2 | |
| SCHEMBL27793494 | 0.81 | CYP4F2 (0.44) | LOXL2TDP1CA12CA2CA9 | |
| SCHEMBL29256723 | 0.79 | KDM4E (0.48) | DYRK1ASIRT3TDP1CA12CA2 | |
| SCHEMBL29159564 | 0.78 | CDK8 (0.47) | DYRK1ASIRT3TDP1CA12CA2 | |
| SCHEMBL21551047 | 0.78 | DYRK1A (0.40) | DYRK1ASIRT3TDP1CA12CA2 | |
| SCHEMBL21582000 | 0.78 | SIRT3 (0.50) | DYRK1ASIRT3TDP1CA12CA2 | |
| SCHEMBL27814739 | 0.77 | ALOX15 (0.43) | DYRK1ALOXL2MAPTMAP4K4PRKACA | |
| SCHEMBL27793488 | 0.77 | ALOX15 (0.43) | LOXL2TDP1CA12CA2CA9 | |
| SCHEMBL31357097 | 0.77 | DYRK1A (0.41) | DYRK1AKMT2AKDM4EMEN1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024249642-A1 | EGFR INHIBITORS | ACERAND THERAPEUTICS (HONG KONG) LIMITED (CN) | 2024-12-05 | — | — | WO | disclosed |
| CN-116997548-A | HTT modulators for the treatment of huntington's disease | CHDI基金会股份有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-111801328-B | Autotaxin inhibitors and uses thereof | 四川海思科制药有限公司 | 2023-06-02 | — | — | CN | disclosed |
| EP-3728257-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | Fronthera U.S. Pharmaceuticals LLC (US) | 2020-10-28 | — | — | EP | disclosed |
| CN-111801328-A | Autotaxin inhibitors and uses thereof | 弗朗塞拉美国制药有限责任公司 | 2020-10-20 | — | — | CN | disclosed |
| WO-2019228403-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2019-12-05 | — | — | WO | disclosed |