Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17132381 | 0.84 | HTT (0.50) | ERN1HTTMAPTALDH1A1PKM | |
| SCHEMBL29155725 | 0.83 | ERN1 (0.44) | ERN1HTTMAPTCRHBPCRHR2 | |
| SCHEMBL30318939 | 0.82 | HTT (0.45) | ERN1HTTMAPTALDH1A1PKM | |
| SCHEMBL5565950 | 0.77 | ALDH1A1 (0.50) | ERN1HTTMAPTCRHBPCRHR2 | |
| SCHEMBL1437010 | 0.76 | ERN1 (0.62) | ERN1HTTMAPTALDH1A1PKM | |
| SCHEMBL19732194 | 0.76 | ACHE (0.48) | HTTMAPTALDH1A1KMT2ATSHR | |
| SCHEMBL10325884 | 0.76 | HTT (0.51) | ERN1HTTMAPTALDH1A1PKM | |
| SCHEMBL8334546 | 0.75 | KMT2A (0.52) | ERN1HTTMAPTALDH1A1PKM | |
| SCHEMBL21582162 | 0.75 | TSHR (0.45) | HTTALDH1A1KMT2ATSHRAPOBEC3A | |
| SCHEMBL21582165 | 0.75 | TSHR (0.49) | HTTALDH1A1TSHRAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3938350-A1 | 3-(2-BROM-4-ALKYNYL-6-ALKOXYPHENYL)-SUBSTITUTED 5-SPIROCYCLOHEXYL-3-PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | Bayer Aktiengesellschaft (DE) | 2022-01-19 | — | — | EP | disclosed |
| EP-3938348-A1 | NOVEL 3-(2-BROM-4-ALKYNYL-6-ALKOXYPHENYL)-3-PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | Bayer Aktiengesellschaft (DE) | 2022-01-19 | — | — | EP | disclosed |
| CN-113557231-A | Novel 3- (2-bromo-4-alkynyl-6-alkoxyphenyl) -3-pyrrolin-2-ones and their use as herbicides | 拜耳公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-113544119-A | 3- (2-bromo-4-alkynyl-6-alkoxyphenyl) -substituted 5-spirocyclohexyl-3-pyrrolin-2-ones and their use as herbicides | 拜耳公司 | 2021-10-22 | — | — | CN | disclosed |
| EP-3793977-A1 | 2-BROMO-6-ALKOXYPHENYL-SUBSTITUTED PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | Bayer Aktiengesellschaft (DE) | 2021-03-24 | — | — | EP | disclosed |
| CN-112334446-A | 2-bromo-6-alkoxyphenyl-substituted pyrrolin-2-ones and their use as herbicides | 拜耳公司 | 2021-02-05 | — | — | CN | disclosed |
| WO-2020187627-A1 | NOVEL 3-(2-BROM-4-ALKYNYL-6-ALKOXYPHENYL)-3-PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-09-24 | — | — | WO | disclosed |
| WO-2020187629-A1 | 3-(2-BROM-4-ALKYNYL-6-ALKOXYPHENYL)-SUBSTITUTED 5-SPIROCYCLOHEXYL-3-PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-09-24 | — | — | WO | disclosed |
| WO-2019228788-A1 | 2-BROMO-6-ALKOXYPHENYL-SUBSTITUTED PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2019-12-05 | — | — | WO | disclosed |