Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848319 | 0.91 | PRKAB2 (0.50) | OPRD1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2159734 | 0.91 | OPRD1 (0.47) | OPRD1PTGS1PTGS2PRKAB2PRKAG1 | |
| SCHEMBL2158949 | 0.89 | PTGS1 (0.48) | OPRD1PTGS1PTGS2PRKAB2PRKAG1 | |
| SCHEMBL2158540 | 0.87 | OPRD1 (0.67) | OPRD1PTGS1PTGS2PRKAB2PRKAG1 | |
| SCHEMBL2158887 | 0.84 | PTGS1 (0.55) | OPRD1PTGS1PTGS2MAPK14KDM4E | |
| SCHEMBL2158549 | 0.82 | MEN1 (0.44) | OPRD1PTGS1PTGS2PRKAB2PRKAG1 | |
| SCHEMBL1849260 | 0.82 | MAPK14 (0.43) | OPRD1PTGS1PTGS2PRKAB2PRKAG1 | |
| SCHEMBL2158460 | 0.82 | MAPK14 (0.42) | OPRD1PTGS1PTGS2PRKAB2PRKAG1 | |
| SCHEMBL15063039 | 0.81 | MAPK14 (0.41) | OPRD1PTGS1PTGS2PRKAB2PRKAG1 | |
| SCHEMBL1848218 | 0.80 | OPRD1 (0.55) | OPRD1PTGS1PTGS2PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410137-B2 | Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-04-02 | — | — | US | disclosed |
| US-20110183960-A1 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183960-A1 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | NR3C2, NR1H3, NR1H2 | OPRD1 45/4885PTGS1 1510/4885PTGS2 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.