Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclothiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.85 |
| ▸ | THRB | P10828 | 2/20 | 0.85 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.85 |
| ▸ | BLM | P54132 | 2/20 | 0.85 |
| ▸ | MEN1 | O00255 | 1/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.85 |
| ▸ | PKM | P14618 | 1/20 | 0.85 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.85 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.85 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.85 |
| ▸ | RECQL | P46063 | 1/20 | 0.85 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.85 |
| ▸ | CA1 | P00915 | 3/20 | 0.69 |
| ▸ | CA2 | P00918 | 2/20 | 0.69 |
| ▸ | CA7 | P43166 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclothiazide SCHEMBL121096 | 0.92 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclothiazide SCHEMBL1362539 | 0.92 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclothiazide SCHEMBL22823942 | 0.92 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| SCHEMBL22824000 | 0.89 | LMNA (0.92) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclothiazide SCHEMBL28086372 | 0.87 | LMNA (0.76) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Trichlormethiazide SCHEMBL25493 | 0.83 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Trichlormethiazide SCHEMBL29356280 | 0.83 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Trichlormethiazide SCHEMBL25492 | 0.83 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclothiazide SCHEMBL28279779 | 0.82 | LMNA (0.78) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclothiazide SCHEMBL28086726 | 0.81 | LMNA (0.76) | LMNACYP3A4KMT2ATHRBCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3579839-A1 | USE OF A COMPOUND OF THE DIURETICS CLASS FOR TREATING CANCER | AZELEAD (FR) | 2019-12-18 | — | — | EP | disclosed |