Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclothiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | THRB | P10828 | 2/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | PKM | P14618 | 1/20 | 0.78 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.78 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.78 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.78 |
| ▸ | RECQL | P46063 | 1/20 | 0.78 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.78 |
| ▸ | BLM | P54132 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclothiazide SCHEMBL22823942 | 0.89 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclothiazide SCHEMBL1362539 | 0.89 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclothiazide SCHEMBL121096 | 0.89 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclopenthiazide SCHEMBL30561852 | 0.86 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclopenthiazide SCHEMBL49142 | 0.86 | LMNA (1.00) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| SCHEMBL22824000 | 0.85 | LMNA (0.92) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| SCHEMBL29132641 | 0.85 | LMNA (0.98) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| SCHEMBL30561876 | 0.85 | LMNA (0.98) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclopenthiazide SCHEMBL9505656 | 0.84 | LMNA (0.96) | LMNACYP3A4KMT2ATHRBCHRM1 | |
| Cyclothiazide SCHEMBL7614349 | 0.82 | LMNA (0.73) | LMNACYP3A4KMT2ATHRBCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109475645-A | MicroRNA composition and its preparation and application | 先进瑞金医疗技术有限公司 | 2019-03-15 | — | — | CN | disclosed |