Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.63 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.63 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.63 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | FPR2 | P25090 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25433785 | 0.84 | POLB (0.64) | KCNQ3KCNQ2SORT1P4HTMHDAC1 | |
| SCHEMBL30354918 | 0.84 | POLB (0.64) | KCNQ3KCNQ2SORT1P4HTMHDAC1 | |
| SCHEMBL4810074 | 0.84 | KCNQ3 (0.63) | KCNQ3KCNQ2SORT1TRPV1P4HTM | |
| SCHEMBL13947518 | 0.84 | KCNQ3 (0.67) | KCNQ3KCNQ2P4HTMKMT2AMAPT | |
| SCHEMBL31110262 | 0.84 | KCNQ3 (0.67) | KCNQ3KCNQ2P4HTMKMT2AMAPT | |
| SCHEMBL15219348 | 0.82 | KCNQ3 (0.60) | KCNQ3KCNQ2SORT1P4HTMHDAC1 | |
| SCHEMBL12921258 | 0.82 | RAB9A (0.66) | KCNQ3KCNQ2P4HTMMEN1KMT2A | |
| SCHEMBL17624571 | 0.81 | CYP11B1 (0.51) | KCNQ3KCNQ2SORT1CYP11B1CYP11B2 | |
| SCHEMBL30354781 | 0.80 | CYP11B1 (0.65) | KCNQ3KCNQ2CYP11B1CYP11B2P4HTM | |
| SCHEMBL30354820 | 0.80 | KCNQ3 (0.65) | KCNQ3KCNQ2SORT1P4HTMKCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |