Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 5/20 | 0.63 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.63 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.53 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15219348 | 0.85 | KCNQ3 (0.60) | KCNQ3KCNQ2P4HTMKCNE1KCNQ1 | |
| SCHEMBL21590155 | 0.84 | KCNQ3 (0.63) | KCNQ3KCNQ2P4HTMTRPV1KCNE1 | |
| SCHEMBL30354918 | 0.84 | POLB (0.64) | KCNQ3KCNQ2P4HTMKCNE1KCNQ1 | |
| SCHEMBL25433785 | 0.84 | POLB (0.64) | KCNQ3KCNQ2P4HTMKCNE1KCNQ1 | |
| SCHEMBL13947518 | 0.84 | KCNQ3 (0.67) | KCNQ3KCNQ2P4HTMNAMPTNPC1 | |
| SCHEMBL31110262 | 0.84 | KCNQ3 (0.67) | KCNQ3KCNQ2P4HTMNAMPTNPC1 | |
| SCHEMBL12921258 | 0.82 | RAB9A (0.66) | KCNQ3KCNQ2P4HTMNAMPTNPC1 | |
| SCHEMBL30354781 | 0.80 | CYP11B1 (0.65) | KCNQ3KCNQ2P4HTMNPC1RAB9A | |
| SCHEMBL3674376 | 0.79 | TRPV1 (0.76) | TRPV1NPC1RAB9APTPN1 | |
| SCHEMBL21258508 | 0.78 | RAB9A (0.81) | P4HTMTRPV1NAMPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
| WO-2008004117-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PDE5A, PDE3B, PDE12 | KCNQ3 1284/4885KCNQ2 1280/4885P4HTM 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.