Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22527782 | 0.94 | MAPT (0.55) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL29392033 | 0.94 | MAPT (0.55) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL17935301 | 0.85 | MAPT (0.64) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL26913723 | 0.84 | KMT2A (0.61) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL26913727 | 0.84 | KMT2A (0.61) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL19857882 | 0.83 | MAPT (0.61) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL19857884 | 0.83 | MAPT (0.61) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL28754392 | 0.82 | HCAR3 (0.83) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL16407597 | 0.82 | MAPT (0.64) | MAPTALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL28754393 | 0.82 | HCAR3 (0.83) | MAPTALDH1A1CYP2C19CYP1A2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |