Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 6/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | GPR4 | P46093 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20510354 | 0.89 | EGLN2 (0.49) | EGLN2ACACBGPR119CYP11B2PARP1 | |
| SCHEMBL21594504 | 0.85 | MAPT (0.47) | GPR119 | |
| SCHEMBL21590390 | 0.83 | TMEM97 (0.36) | CYP11B2 | |
| SCHEMBL20468837 | 0.80 | CYP11B2 (0.49) | EGLN2ACACBGPR119CYP11B2PARP1 | |
| SCHEMBL20468832 | 0.80 | CYP11B2 (0.52) | EGLN2ACACBGPR119CYP11B2RORC | |
| SCHEMBL20468835 | 0.80 | ACACB (0.49) | ACACBCYP11B2RORCPARP1RET | |
| SCHEMBL12811247 | 0.78 | EGLN2 (0.48) | EGLN2ACACBGPR119CYP11B2KRAS | |
| SCHEMBL7898697 | 0.77 | MAPT (0.51) | EGLN2GPR119 | |
| SCHEMBL21711129 | 0.77 | CYP11B2 (0.53) | ACACBCYP11B2PARP1RETSCD5 | |
| SCHEMBL20469135 | 0.77 | CYP11B2 (0.53) | ACACBCYP11B2PARP1RETSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807271-A1 | PYRIDINYL HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2021-04-21 | — | — | EP | disclosed |
| WO-2019238629-A1 | PYRIDINYL HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2019-12-19 | — | — | WO | disclosed |