Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.45 |
| ▸ | AKT2 | P31751 | 2/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158626 | 1.00 | AKT1 (0.45) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL2159120 | 1.00 | AKT1 (0.45) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL12395979 | 1.00 | AKT1 (0.45) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL2158631 | 1.00 | AKT1 (0.45) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL2158370 | 0.91 | DRD2 (0.51) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL2158854 | 0.91 | DRD2 (0.51) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL2158371 | 0.91 | DRD2 (0.51) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL2158859 | 0.91 | DRD2 (0.51) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL12395976 | 0.91 | DRD2 (0.51) | AKT1AKT2AKT3CYP3A4ROCK2 | |
| SCHEMBL12464209 | 0.86 | HRH4 (0.47) | CYP3A4CNR1KDM4EMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170209586-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2017-07-27 | — | — | US | disclosed |
| US-9597403-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2017-03-21 | — | — | US | disclosed |
| EP-2987789-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2016-02-24 | — | — | EP | disclosed |
| US-20140287050-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM, INC. (US) | 2014-09-25 | — | — | US | disclosed |
| US-8715699-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2012-11-01 | — | — | US | disclosed |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | AKT1 2923/4885AKT2 3238/4885AKT3 2832/4885 |
| US-20170209586-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | QPCT, AADAT, SLC1A5 | AKT1 2815/4885AKT2 3299/4885AKT3 2929/4885 |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | AKT1 2923/4885AKT2 3238/4885AKT3 2832/4885 |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | AKT1 2925/4885AKT2 3206/4885AKT3 2764/4885 |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | SLC1A5, QPCT, SLC6A15 | AKT1 3166/4885AKT2 3385/4885AKT3 2940/4885 |
| US-20140287050-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | QPCT, SLC1A5, SLC1A2 | AKT1 2925/4885AKT2 3206/4885AKT3 2764/4885 |
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | QPCT, SLC1A5, SLC1A2 | AKT1 2923/4885AKT2 3238/4885AKT3 2832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.