SCHEMBL21591468

SCHEMBL21591468

Cc1ccc2c(=O)c(CN(CCCn3cnc4c(Cl)ncnc43)Cc3ccncc3)c(C)oc2c1C

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 6/20 0.31
▸ FGFR4 P22455 6/20 0.31
▸ P2RX7 Q99572 2/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ ALOX15 P16050 1/20 0.31
▸ HDAC6 Q9UBN7 1/20 0.31
▸ YTHDC1 Q96MU7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21592258 0.91 ADORA2A (0.39) FGFR1
SCHEMBL21591477 0.86 HPRT1 (0.39) —
SCHEMBL21591500 0.73 HDAC3 (0.41) ALDH1A1HDAC6
SCHEMBL31361801 0.73 HDAC3 (0.41) ALDH1A1HDAC6
SCHEMBL21592263 0.71 POLB (0.34) ALDH1A1
SCHEMBL21591523 0.68 LTA4H (0.31) —
SCHEMBL21592266 0.67 ALDH1A1 (0.41) ALDH1A1
SCHEMBL21591449 0.66 SMN1; SMN2 (0.35) ALDH1A1ALOX15
SCHEMBL21591439 0.66 CYP11B1 (0.37) ALDH1A1ALOX15
SCHEMBL21591515 0.63 FGFR1 (0.45) FGFR1FGFR4P2RX7ALDH1A1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12162863-B2 Modulators of stimulator of interferon genes (STING) Ryvu Therapeutics S.A. (PL) 2024-12-10 — — US disclosed
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2022-12-22 — — US disclosed
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2022-12-22 — — US disclosed
EP-3807264-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2021-04-21 — — EP disclosed
WO-2019238786-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2019-12-19 — — WO disclosed
WO-2019238786-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2019-12-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12162863-B2 Modulators of stimulator of interferon genes (STING) STING1, IRF3, CGAS FGFR1 2759/4885FGFR4 3186/4885P2RX7 273/4885
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) STING1, IRF3, CGAS FGFR1 2759/4885FGFR4 3186/4885P2RX7 273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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