Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 5/20 | 0.40 |
| ▸ | NOS2 | P35228 | 5/20 | 0.38 |
| ▸ | NOS1 | P29475 | 5/20 | 0.38 |
| ▸ | NOS3 | P29474 | 4/20 | 0.38 |
| ▸ | GSR | P00390 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL21592230 | 1.00 | OTC (0.43) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL26104827 | 0.96 | OTC (0.36) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL9314458 | 0.94 | OTC (0.35) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL28623187 | 0.90 | OTC (0.39) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL27530824 | 0.89 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL150228 | 0.89 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL248897 | 0.89 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL27692295 | 0.89 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL150229 | 0.89 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Malic Acid SCHEMBL11164058 | 0.88 | SMN1; SMN2 (0.40) | OTCDDAH1NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3065730-B1 | VASODILATOR FORMULATION AND METHOD OF USE | ATP INST PTY LTD (AU) | 2019-12-25 | — | — | EP | disclosed |