Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 15/20 | 0.67 |
| ▸ | IL2 | P60568 | 5/20 | 0.67 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592574 | 0.88 | MAP4K1 (0.78) | MAP4K1IL2MAP3K11LCKMAP4K3 | |
| SCHEMBL21592483 | 0.85 | MAP4K1 (0.64) | MAP4K1IL2RPS6KA3TNIK | |
| SCHEMBL21592491 | 0.85 | MAP4K1 (0.75) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL30290612 | 0.84 | MAP4K1 (0.71) | MAP4K1IL2LCKMAP4K3RPS6KA3 | |
| SCHEMBL28684672 | 0.84 | MAP4K1 (0.71) | MAP4K1IL2LCKMAP4K3RPS6KA3 | |
| Hydrochloric Acid SCHEMBL28905282 | 0.84 | MAP4K1 (0.74) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL21592466 | 0.82 | MAP4K1 (0.78) | MAP4K1IL2MAP3K11LCKMAP4K3 | |
| SCHEMBL21592482 | 0.81 | TNIK (0.59) | MAP4K1IL2MAP3K11RPS6KA3TNIK | |
| SCHEMBL21592486 | 0.81 | MAP4K1 (0.72) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL21592585 | 0.81 | MAP4K1 (0.69) | MAP4K1IL2MAP3K11TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |