Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215924 | 1.00 | HPGD (0.68) | HPGDADAMTS5SIRT6MAPTALDH1A1 | |
| SCHEMBL10360254 | 0.89 | HPGD (0.68) | HPGDADAMTS5SIRT6MAPTALDH1A1 | |
| SCHEMBL16262194 | 0.87 | SIRT6 (0.54) | HPGDSIRT6MAPTALDH1A1CYP2C19 | |
| SCHEMBL16262196 | 0.87 | SIRT6 (0.54) | HPGDSIRT6MAPTALDH1A1CYP2C19 | |
| SCHEMBL25787624 | 0.85 | HPGD (0.63) | HPGDADAMTS5SIRT6MAPTALDH1A1 | |
| SCHEMBL14432027 | 0.84 | HPGD (0.69) | HPGDADAMTS5SIRT6MAPTALDH1A1 | |
| SCHEMBL7050664 | 0.84 | HPGD (0.88) | HPGDSIRT6MAPTALDH1A1CYP2C19 | |
| SCHEMBL17958719 | 0.83 | SMN1; SMN2 (0.54) | SIRT6MAPTALDH1A1CYP2C19DCTPP1 | |
| SCHEMBL213791 | 0.83 | LMNA (0.69) | HPGDSIRT6MAPTALDH1A1CYP2C19 | |
| SCHEMBL17958720 | 0.83 | SMN1; SMN2 (0.54) | SIRT6MAPTALDH1A1CYP2C19DCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024141052-A1 | ESTROGEN-RECEPTOR MODULATOR AND USE THEREOF | 江苏威凯尔医药科技有限公司 | 2024-07-04 | — | — | WO | disclosed |
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | JAK2, JAK1, JAK3 | HPGD 3138/4885ADAMTS5 1878/4885SIRT6 3316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.