Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.56 |
| ▸ | IL2 | P60568 | 3/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.55 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592626 | 0.90 | TNIK (0.56) | NTRK1PIK3CGMAP4K1IL2TNIK | |
| SCHEMBL28513938 | 0.89 | MAP4K1 (0.56) | MAP4K1IL2TNIKMAP3K11 | |
| SCHEMBL21592503 | 0.87 | MAP4K1 (0.71) | NTRK1MAP4K1IL2TNIKMAP3K11 | |
| SCHEMBL28507129 | 0.87 | TNIK (0.59) | NTRK1MAP4K1IL2TNIKMAP3K11 | |
| SCHEMBL28503427 | 0.87 | MAP4K1 (0.54) | PIK3CGMAP4K1IL2TNIKMAP3K11 | |
| SCHEMBL21592736 | 0.86 | MAP4K1 (0.53) | NTRK1MAP4K1IL2TNIKMAP3K11 | |
| SCHEMBL21592582 | 0.86 | TNIK (0.54) | NTRK1PIK3CGMAP4K1IL2TNIK | |
| SCHEMBL28510217 | 0.86 | MAP4K1 (0.56) | PIK3CGMAP4K1IL2TNIKMAP3K11 | |
| SCHEMBL28517248 | 0.85 | MAP4K1 (0.64) | PIK3CGMAP4K1IL2TNIKMAP3K11 | |
| SCHEMBL21592667 | 0.84 | KIT (0.55) | MAP4K1IL2TNIKMAP3K11KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |