Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 9/20 | 0.52 |
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.50 |
| ▸ | IL2 | P60568 | 3/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | CHUK | O15111 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592630 | 0.86 | NTRK1 (0.58) | MAP4K1TNIKMAP3K11IL2NTRK1 | |
| SCHEMBL28513938 | 0.85 | MAP4K1 (0.56) | MAP4K1TNIKMAP3K11IL2IKBKB | |
| SCHEMBL28507129 | 0.83 | TNIK (0.59) | MAP4K1TNIKMAP3K11IL2IKBKB | |
| SCHEMBL28503427 | 0.83 | MAP4K1 (0.54) | MAP4K1TNIKMAP3K11IL2IKBKB | |
| SCHEMBL21592582 | 0.83 | TNIK (0.54) | MAP4K1TNIKMAP3K11IL2NTRK1 | |
| SCHEMBL21592626 | 0.83 | TNIK (0.56) | MAP4K1TNIKMAP3K11IL2CDK2 | |
| SCHEMBL28510217 | 0.83 | MAP4K1 (0.56) | MAP4K1TNIKMAP3K11IL2IKBKB | |
| SCHEMBL28517248 | 0.82 | MAP4K1 (0.64) | MAP4K1TNIKMAP3K11IL2SGK1 | |
| SCHEMBL21592832 | 0.81 | MAP3K11 (0.54) | MAP4K1TNIKMAP3K11IL2IKBKB | |
| SCHEMBL21592667 | 0.81 | KIT (0.55) | MAP4K1TNIKMAP3K11IL2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |