Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592694 | 0.89 | MAP4K1 (0.49) | MAP4K1MAPK1MAP3K11JAK2JAK1 | |
| SCHEMBL21592436 | 0.87 | MAP4K1 (0.64) | MAP4K1MAPK1MAP3K11JAK2JAK1 | |
| SCHEMBL21592484 | 0.85 | MAP4K1 (0.61) | MAP4K1MAPK1MAP3K11 | |
| SCHEMBL21592675 | 0.84 | MAP3K11 (0.64) | MAP4K1MAP3K11 | |
| SCHEMBL21592764 | 0.82 | MAP4K1 (0.52) | MAP4K1MAPK1MAP3K11JAK2JAK1 | |
| SCHEMBL21592955 | 0.81 | MAP4K1 (0.53) | MAP4K1MAPK1HRH3JAK2JAK1 | |
| SCHEMBL21592544 | 0.81 | MAP4K1 (0.67) | MAP4K1MAPK1MAP3K11JAK2 | |
| SCHEMBL21592951 | 0.80 | MAP4K1 (0.60) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL21592703 | 0.80 | MAP4K1 (0.50) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL21592476 | 0.77 | MAP4K1 (0.62) | MAP4K1MAP3K11JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |