Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593108 | 0.92 | NR1H2 (0.42) | NR1H2ESR2HTR6ACACBALDH1A1 | |
| SCHEMBL21593191 | 0.91 | NR1H2 (0.38) | NR1H2ESR2HTR6ACACBALDH1A1 | |
| SCHEMBL21593173 | 0.90 | NR1H2 (0.39) | NR1H2ESR2HTR6ACACB | |
| SCHEMBL21593189 | 0.90 | NR1H2 (0.37) | NR1H2ESR2HTR6ACACBALDH1A1 | |
| SCHEMBL21593192 | 0.89 | NR1H2 (0.38) | NR1H2HDAC8MMP13ADAM17MMP1 | |
| SCHEMBL29836554 | 0.89 | NR1H2 (0.38) | NR1H2HDAC8MMP13ADAM17MMP1 | |
| SCHEMBL21593118 | 0.88 | NR1H2 (0.36) | NR1H2HTR6ACACBGPR119MMP13 | |
| SCHEMBL23762175 | 0.87 | UCHL1 (0.35) | NR1H2HDAC8MMP13ADAM17MMP1 | |
| SCHEMBL23762177 | 0.87 | WNT3A (0.35) | NR1H2ESR2HTR6ACACBHDAC8 | |
| SCHEMBL23762216 | 0.87 | ACACB (0.36) | NR1H2ESR2HTR6ACACBHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | disclosed |