Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 5/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | ABL2 | P42684 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593108 | 0.91 | NR1H2 (0.42) | NR1H2UCHL1SRCEGFRABL1 | |
| SCHEMBL23762168 | 0.87 | ACHE (0.39) | NR1H2CYP3A4HTR6 | |
| SCHEMBL21593086 | 0.85 | NR1H2 (0.44) | NR1H2CYP3A4ESR2KITHTR6 | |
| SCHEMBL21593175 | 0.83 | NR1H2 (0.36) | NR1H2UCHL1SRCEGFRABL1 | |
| SCHEMBL21593106 | 0.83 | NR1H2 (0.39) | NR1H2ESR2KITHTR6GPR119 | |
| SCHEMBL21593191 | 0.82 | NR1H2 (0.38) | NR1H2ESR2KITHTR6GPR119 | |
| SCHEMBL21593192 | 0.81 | NR1H2 (0.38) | NR1H2UCHL1 | |
| SCHEMBL29836554 | 0.81 | NR1H2 (0.38) | NR1H2UCHL1 | |
| SCHEMBL21593173 | 0.81 | NR1H2 (0.39) | NR1H2ESR2HTR6 | |
| SCHEMBL21593189 | 0.81 | NR1H2 (0.37) | NR1H2ESR2KITHTR6GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | disclosed |