Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30694896 | 0.87 | GABRA1 (0.38) | GABRA1GABRA5TAS2R8 | |
| SCHEMBL23150882 | 0.87 | GABRA1 (0.38) | GABRA1GABRA5TAS2R8 | |
| SCHEMBL21590977 | 0.87 | GABRA1 (0.38) | GABRA1GABRA5TAS2R8 | |
| SCHEMBL30694841 | 0.87 | GABRA1 (0.38) | GABRA1GABRA5TAS2R8 | |
| SCHEMBL30694843 | 0.85 | GABRA1 (0.37) | GABRA1GABRA5 | |
| SCHEMBL21590900 | 0.85 | GABRA1 (0.37) | GABRA1GABRA5 | |
| SCHEMBL21590573 | 0.85 | GABRA1 (0.37) | GABRA1ALDH1A1GABRA5 | |
| SCHEMBL21593268 | 0.85 | GABRA1 (0.37) | GABRA1ALDH1A1GABRA5 | |
| SCHEMBL21593336 | 0.84 | GABRA1 (0.39) | GABRA1 | |
| SCHEMBL21590915 | 0.84 | GABRA1 (0.36) | GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238633-A1 | NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2019-12-19 | — | — | WO | disclosed |