Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 17/20 | 0.38 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590977 | 1.00 | GABRA1 (0.38) | GABRA1TAS2R8GABRA5 | |
| SCHEMBL30694896 | 1.00 | GABRA1 (0.38) | GABRA1TAS2R8GABRA5 | |
| SCHEMBL23150882 | 1.00 | GABRA1 (0.38) | GABRA1TAS2R8GABRA5 | |
| SCHEMBL21590745 | 0.91 | GABRA1 (0.43) | GABRA1 | |
| SCHEMBL21590902 | 0.91 | GABRA1 (0.43) | GABRA1 | |
| SCHEMBL21590900 | 0.88 | GABRA1 (0.37) | GABRA1GABRA5 | |
| SCHEMBL30694843 | 0.88 | GABRA1 (0.37) | GABRA1GABRA5 | |
| SCHEMBL21593337 | 0.87 | GABRA1 (0.39) | GABRA1TAS2R8GABRA5 | |
| SCHEMBL21590915 | 0.87 | GABRA1 (0.36) | GABRA1 | |
| SCHEMBL21590739 | 0.87 | GABRA1 (0.36) | GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840528-B2 | Isoxazolyl ether derivatives as GABAA α5 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-12-12 | — | — | US | claimed |
| US-11840528-B2 | Isoxazolyl ether derivatives as GABAA α5 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11840528-B2 | Isoxazolyl ether derivatives as GABAA α5 PAM | GABRA5, GABRA2, GABRB2 | GABRA1 4/4885TAS2R8 553/4885GABRA5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.