Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 10/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600965 | 0.90 | JAK3 (0.60) | FGFR1FGFR4JAK3MAPK3MAPK1 | |
| SCHEMBL21600959 | 0.88 | JAK3 (0.58) | FGFR1FGFR4JAK3MAPK3MAPK1 | |
| SCHEMBL21596379 | 0.88 | PLK1 (0.56) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21600938 | 0.87 | EGFR (0.50) | PLK1JAK3MAPK3MAPK1EGFR | |
| SCHEMBL21600908 | 0.86 | JAK3 (0.51) | PLK1FGFR4JAK3MAPK3EGFR | |
| SCHEMBL28546192 | 0.85 | PLK1 (0.57) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL25139771 | 0.84 | PLK1 (0.60) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL30043654 | 0.84 | PLK1 (0.60) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28537291 | 0.84 | PLK1 (0.63) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28531630 | 0.84 | MAPK3 (0.51) | PLK1JAK3MAPK3MAPK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |