Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 9/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.63 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.63 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | TTK | P33981 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28546192 | 0.88 | PLK1 (0.57) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21596347 | 0.84 | PLK1 (0.56) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21596379 | 0.83 | PLK1 (0.56) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28953574 | 0.81 | ALK (0.53) | ALKIGF1R | |
| SCHEMBL28537191 | 0.79 | EGFR (0.67) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL30379611 | 0.76 | FGFR1 (0.49) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28532459 | 0.76 | FGFR1 (0.49) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28600015 | 0.76 | MAPK10 (0.52) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28531632 | 0.74 | FGFR1 (0.47) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28546939 | 0.74 | TTK (0.43) | PLK1FGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |