Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 7/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600800 | 0.90 | JAK3 (0.48) | EGFRJAK3FGFR4FGFR1MAPK3 | |
| SCHEMBL21596338 | 0.87 | FGFR4 (0.51) | EGFRJAK3FGFR4FGFR1MAPK3 | |
| SCHEMBL21600869 | 0.86 | CDK7 (0.59) | EGFRJAK3FGFR1BTKKDR | |
| SCHEMBL30380016 | 0.86 | CDK7 (0.59) | EGFRJAK3FGFR1BTKKDR | |
| SCHEMBL30379294 | 0.86 | MAPK3 (0.55) | EGFRJAK3FGFR1MAPK3MAP3K7 | |
| SCHEMBL21600757 | 0.86 | MAPK3 (0.55) | EGFRJAK3FGFR1MAPK3MAP3K7 | |
| SCHEMBL28546954 | 0.86 | EGFR (0.48) | EGFRJAK3FGFR4FGFR1MAPK3 | |
| SCHEMBL21600975 | 0.85 | JAK3 (0.44) | EGFRJAK3FGFR4FGFR1MAPK3 | |
| SCHEMBL21600754 | 0.85 | JAK3 (0.52) | EGFRJAK3FGFR4FGFR1MAPK3 | |
| SCHEMBL21600786 | 0.85 | MAPK3 (0.52) | EGFRJAK3FGFR4FGFR1MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |