Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 4/20 | 0.59 |
| ▸ | CCNH | P51946 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.59 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 12/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30380016 | 1.00 | CDK7 (0.59) | CDK7CCNHFLT3CDK1CCNB1 | |
| SCHEMBL21601000 | 0.89 | EGFR (0.54) | CDK7CCNHFLT3CDK1CCNB1 | |
| SCHEMBL21596372 | 0.88 | FLT3 (0.57) | CDK7CCNHFLT3CDK1CCNB1 | |
| SCHEMBL28537409 | 0.88 | EGFR (0.58) | CDK7CCNHFLT3CDK1CCNB1 | |
| SCHEMBL28537293 | 0.88 | FGFR1 (0.47) | CDK7CCNHFLT3CDK1CCNB1 | |
| SCHEMBL21600999 | 0.87 | CDK7 (0.56) | CDK7CCNHFLT3CDK1CCNB1 | |
| SCHEMBL21596397 | 0.86 | EGFR (0.49) | EGFRIGF1RJAK3CDK2FGFR1 | |
| SCHEMBL21601001 | 0.86 | CDK7 (0.55) | CDK7CCNHFLT3CDK1CCNB1 | |
| SCHEMBL28542726 | 0.84 | FLT3 (0.59) | CDK7CCNHFLT3CDK1CCNB1 | |
| SCHEMBL21600798 | 0.84 | EGFR (0.51) | CDK7CCNHFLT3CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |